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ANTONYM OF ELUCIDATE MANUAL
This study suggests L47P, G54W, and G250C/D deleterious mutations as priorities for future studies on SHANK3.Īutism Neuropsychiatric disorders SHANK3 Single-nucleotide polymorphism.Ībraham M, Van Der Spoel D, Lindahl E, Hess B (2014) The GROMACS development team GROMACS user manual Versio 5Īdzhubei IA et al (2010) A method and server for predicting damaging missense mutations. We've arranged the synonyms in length order so that they are easier to find. G250C/D and G635R consensus deleterious mutations were found in the first and second binding domains of SHANK3, and none were found in the post-translational modification sites. Synonyms, crossword answers and other related words for ELUCIDATE We hope that the following list of synonyms for the word elucidate will help you to finish your crossword today. Translations Monolingual examples Synonyms Conjugation.
ANTONYM OF ELUCIDATE FREE
Simulation revealed significant changes in intramolecular interactions and high fluctuations in residues of 1-350 that significantly affect the ANK functional domain. Translation for elucidating in the free English-Romanian dictionary and many other Romanian. Stability analyses introduced L47P, G54W, and G250D as the most destabilizing mutations, thus they were subjected to molecular dynamics simulation. Mutations, including L47P, G54W, G172D, G250C/D, and G627E, which posed drastic effects on the secondary structure of SHANK3, were modeled. Twenty-nine missense variants were unanimously recognized as deleterious and subjected to structural and stability analyses. Missense variants were categorized as deleterious or non-deleterious. Various databases were used to extract 16,894 non-redundant SNPs, out of which 1179 were annotated as missense variants.
In this study, the functional and structural impacts of non-synonymous single-nucleotide polymorphisms (SNPs) on SHANK3 were predicted.
Mutations in SHANK3 have been linked to a number of neuropsychiatric and neurodevelopmental disorders, including autism spectrum disorder.
It is the hypothetical source of/evidence for its existence is provided by: Sanskrit rocate "shines " Armenian lois "light," lusin "moon " Greek leukos "bright, shining, white " Latin lucere "to shine," lux "light," lucidus "clear " Old Church Slavonic luci "light " Lithuanian laukas "pale " Welsh llug "gleam, glimmer " Old Irish loche "lightning," luchair "brightness " Hittite lukezi "is bright " Old English leht, leoht "light, daylight spiritual illumination," German Licht, Gothic liuhaþ "light.SHANK3, a member of SH3 and multiple ankyrin repeat domains (SHANK) proteins, plays a crucial role in synaptic development and functions. " lucent lucid Lucifer luciferase luciferous lucifugous lucubrate lucubration luculent lumen Luminal luminary luminate luminescence luminous luna lunacy lunar Lunarian lunate lunation lunatic lune lunette luni- luster lustrum lux pellucid sublunary translucent. It forms all or part of: allumette elucidate illumination illustration lea leukemia leuko- light (n.) "brightness, radiant energy " lightning limn link (n.2) "torch of pitch, tow, etc. Proto-Indo-European root meaning "light, brightness."
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